Extracellular Superoxide Dismutase Is a Major Determinant of Nitric Oxide Bioavailability
نویسندگان
چکیده
منابع مشابه
Bioavailability : In Vivo and Ex Vivo Evidence From ecSOD-Deficient Mice Extracellular Superoxide Dismutase Is a Major Determinant of Nitric Oxide
The bioavailability of nitric oxide (NO) within the vascular wall is limited by superoxide anions (O2 · ). The relevance of extracellular superoxide dismutase (ecSOD) for the detoxification of vascular O2 · is unknown. We determined the involvement of ecSOD in the control of blood pressure and endothelium-dependent responses in angiotensin II–induced hypertension and renovascular hypertension i...
متن کاملExtracellular superoxide dismutase is a major determinant of nitric oxide bioavailability: in vivo and ex vivo evidence from ecSOD-deficient mice.
The bioavailability of nitric oxide (NO) within the vascular wall is limited by superoxide anions (O2.-). The relevance of extracellular superoxide dismutase (ecSOD) for the detoxification of vascular O2.- is unknown. We determined the involvement of ecSOD in the control of blood pressure and endothelium-dependent responses in angiotensin II-induced hypertension and renovascular hypertension in...
متن کاملExtracellular superoxide dismutase is upregulated with inducible nitric oxide synthase after NF-κB activation.
Inflammatory cytokines have been shown to upregulate secretion of the antioxidant enzyme extracellular superoxide dismutase (EC-SOD) in dermal fibroblasts and, in other cells, to stimulate production of nitric oxide (⋅ NO). Because superoxide rapidly scavenges ⋅ NO, forming the injurious peroxynitrite anion (OONO-), we hypothesize that stimulated cells upregulate EC-SOD expression concurrently ...
متن کاملIs Nitric Oxide a Hormone?
Nitric oxide (NO) is a simple ubiquitous signaling molecule and plays important roles in almost every biological system. Recent evidences suggest that NO may act as an endocrine molecule. The aim of this review is considering available literature on endocrine roles of NO and/or its metabolites, i.e. nitrite and nitrate. Existing data suggest the idea that NO is a hormone that after production i...
متن کاملRegulation of the vascular extracellular superoxide dismutase by nitric oxide and exercise training.
The bioactivity of endothelium-derived nitric oxide (NO) reflects its rates of production and of inactivation by superoxide (O(2)(*-)), a reactive species dismutated by extracellular superoxide dismutase (ecSOD). We have now examined the complementary hypothesis, namely that NO modulates ecSOD expression. The NO donor DETA-NO increased ecSOD expression in a time- and dose-dependent manner in hu...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Circulation Research
سال: 2003
ISSN: 0009-7330,1524-4571
DOI: 10.1161/01.res.0000092140.81594.a8